Antimalarial Synergy of Cysteine and Aspartic Protease Inhibitors

It has been proposed that the Plasmodium falciparum cysteine protease falcipain and aspartic proteases plasmepsin I and plasmepsin II act cooperatively to hydrolyze hemoglobin as a source of amino acids for erythrocytic parasites. Inhibitors of each of these proteases have potent antimalarial effect...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Semenov, Andrey, Olson, Jed E., Rosenthal, Philip J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105801/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2254
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