In Vivo Activity and Pharmacokinetic Evaluation of a Novel Long-Acting Carbapenem Antibiotic, MK-826 (L-749,345)

MK-826 (formerly L-749,345), is a potent 1-β-methyl carbapenem with a long half-life and broad spectrum of activity. This compound is presently in phase-II clinical trials. Its activity against a number of gram-positive and gram-negative organisms was compared to those of imipenem (IPM) and eight ot...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Gill, Charles J., Jackson, Jesse J., Gerckens, Lynn S., Pelak, Barbara A., Thompson, Randall K., Sundelof, Jon G., Kropp, Helmut, Rosen, H.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Pharmacology
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105722/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9687396/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.8.1996
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