Immunomodulating Properties of the Antibiotic Novobiocin in Human Monocytes

We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells. It shares these cytokine-suppressin...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Lührmann, Anja, Thölke, Jürgen, Behn, Ingrid, Schumann, Jens, Tiegs, Gisa, Hauschildt, Sunna
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Biologic Response Modifiers
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105709/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9687383/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.8.1911
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