Immunomodulating Properties of the Antibiotic Novobiocin in Human Monocytes

We show that the coumeromycin antibiotic novobiocin, a potent inhibitor of ADP ribosylation, prevents lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), IL-6, and IL-10 secretion in human peripheral blood mononuclear cells. It shares these cytokine-suppressin...

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Bibliografske podrobnosti
Main Authors: Lührmann, Anja, Thölke, Jürgen, Behn, Ingrid, Schumann, Jens, Tiegs, Gisa, Hauschildt, Sunna
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 1998
Teme:
Biologic Response Modifiers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC105709/
https://ncbi.nlm.nih.gov/pubmed/9687383
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