Anti-Hepatitis B Virus Activity and Metabolism of 2′,3′-Dideoxy-2′,3′-Didehydro-β-l(−)-5-Fluorocytidine

2′,3′-Dideoxy-2′,3′-didehydro-β-l(−)-5-fluorocytidine [l(−)Fd4C] was found to be at least 10 times more potent than β-l-2′,3′-dideoxy-3′-thiacytidine [l(−)SddC; also called 3TC, or lamivudine]against hepatitis B virus (HBV) in culture. Its cytotoxicity against HepG2 growth in culture was also greate...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Zhu, Yong-Lian, Dutschman, Ginger E., Liu, Shwu-Huey, Bridges, Edward G., Cheng, Yung-Chi
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105687/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661025/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1805
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