Metabolism of 2′,3′-Dideoxy-2′,3′-Didehydro-β-l(−)-5-Fluorocytidine and Its Activity in Combination with Clinically Approved Anti-Human Immunodeficiency Virus β-d(+) Nucleoside Analogs In Vitro

2′,3′-Dideoxy-2′,3′-didehydro-β-l(−)-5-fluorocytidine [l(−)Fd4C] has been reported to be a potent inhibitor of the human immunodeficiency virus (HIV) in cell culture. In the present study the antiviral activity of this compound in two-drug combinations and its intracellular metabolism are addressed....

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Dutschman, Ginger E., Bridges, Edward G., Liu, Shwu-Huey, Gullen, Elizabeth, Guo, Xin, Kukhanova, Marina, Cheng, Yung-Chi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661024/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1799
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