Pharmacokinetic Evaluation of Amphotericin B in Lung Tissue: Lung Lymph Distribution after Intravenous Injection and Airspace Distribution after Aerosolization and Inhalation of Amphotericin B

We have studied the pharmacokinetics of amphotericin B (AmB) in lung lymph circulation and bronchial-wash fluid after intravenous infusion and inhalation, respectively. For two experiments with awake sheep, we used lung lymph fistulas and tracheotomy. In experiment 1, AmB concentrations in plasma an...

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Main Authors: Koizumi, Tomonobu, Kubo, Keishi, Kaneki, Toshimichi, Hanaoka, Masayuki, Hayano, Toshihide, Miyahara, Takayuki, Okada, Kazuyoshi, Fujimoto, Keisaku, Yamamoto, Hiroshi, Kobayashi, Toshio, Sekiguchi, Morie
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC105652/
https://ncbi.nlm.nih.gov/pubmed/9660990
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