Glucuronidation of 3′-Azido-3′-Deoxythymidine (Zidovudine) by Human Liver Microsomes: Relevance to Clinical Pharmacokinetic Interactions with Atovaquone, Fluconazole, Methadone, and Valproic Acid

Zidovudine (3′-azido-3′-deoxythymidine [AZT]), an antiviral nucleoside analog effective in the treatment of human immunodeficiency virus infection, is primarily metabolized to an inactive glucuronide form, GAZT, via uridine-5′-diphospho-glucuronosyltransferase (UGT) enzymes. UGT enzymes exist as dif...

Полное описание

Библиографические подробности

Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Trapnell, Carol Braun, Klecker, Raymond W., Jamis-Dow, Carlos, Collins, Jerry M.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1998
Предметы:	Antiviral Agents
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105651/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9660989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1592
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!