Glucuronidation of 3′-Azido-3′-Deoxythymidine (Zidovudine) by Human Liver Microsomes: Relevance to Clinical Pharmacokinetic Interactions with Atovaquone, Fluconazole, Methadone, and Valproic Acid

Zidovudine (3′-azido-3′-deoxythymidine [AZT]), an antiviral nucleoside analog effective in the treatment of human immunodeficiency virus infection, is primarily metabolized to an inactive glucuronide form, GAZT, via uridine-5′-diphospho-glucuronosyltransferase (UGT) enzymes. UGT enzymes exist as dif...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Trapnell, Carol Braun, Klecker, Raymond W., Jamis-Dow, Carlos, Collins, Jerry M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105651/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9660989/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1592
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