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Alginate Lyase Promotes Diffusion of Aminoglycosides through the Extracellular Polysaccharide of Mucoid Pseudomonas aeruginosa

We demonstrated that a 2% suspension of Pseudomonas aeruginosa alginate completely blocked the diffusion of gentamicin and tobramycin, but not that of carbenicillin, illustrating how alginate production can help protect P. aeruginosa growing within alginate microcolonies in patients with cystic fibr...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Hatch, Richard A., Schiller, Neal L.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1998
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105585/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9559826/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.4.974
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