Mutations in aarE, the ubiA Homolog of Providencia stuartii, Result in High-Level Aminoglycoside Resistance and Reduced Expression of the Chromosomal Aminoglycoside 2′-N-Acetyltransferase

The aarE1 allele was identified on the basis of the resulting phenotype of increased aminoglycoside resistance. The aarE1 mutation also resulted in a small-colony phenotype and decreased levels of aac(2′)-Ia mRNA. The deduced AarE gene product displayed 61% amino acid identity to the Escherichia col...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Paradise, Michael R., Cook, Gregory, Poole, Robert K., Rather, Philip N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105580/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9559821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.4.959
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