Efficacy of LY303366 against Amphotericin B-Susceptible and -Resistant Aspergillus fumigatus in a Murine Model of Invasive Aspergillosis

LY303366 is a novel antifungal echinocandin with excellent in vitro activity against Aspergillus spp. We compared four doses (1, 2.5, 10, and 25 mg/kg of body weight) of LY303366 with amphotericin B (0.5 to 5 mg/kg) in a temporarily neutropenic murine model of invasive aspergillosis against an ampho...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Verweij, Paul E., Oakley, Karen L., Morrissey, Jacqui, Morrissey, Graham, Denning, David W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105558/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9559799/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.4.873
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