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Cyclosporin Analogs Inhibit In Vitro Growth of Cryptosporidium parvum

Cyclosporine and nonimmunosuppressive cyclosporin (CS) analogs were demonstrated to be potent inhibitors of the growth of the intracellular parasite Cryptosporidium parvum in short-term (48-h) in vitro cultures. Fifty-percent inhibitory concentrations (IC(50)s) were 0.4 μM for SDZ 033-243, 1.0 μM fo...

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Bibliographic Details
Main Authors: Perkins, Margaret E., Wu, Teresa W., Le Blancq, Sylvie M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC105553/
https://ncbi.nlm.nih.gov/pubmed/9559794
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