Use of Pharmacodynamic Parameters To Predict Efficacy of Combination Therapy by Using Fractional Inhibitory Concentration Kinetics

Combination therapy with antimicrobial agents can be used against bacteria that have reduced susceptibilities to single agents. We studied various tobramycin and ceftazidime dosing regimens against four resistant Pseudomonas aeruginosa strains in an in vitro pharmacokinetic model to determine the us...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	den Hollander, Jan G., Mouton, Johan W., Verbrugh, Henri A.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Pharmacology
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9559776/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.4.744
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