Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro

We have investigated the contribution of drug accumulation and inhibition of heme polymerization to the in vitro activities of a series of antimalarial drugs. Only those compounds exhibiting structural relatedness to the quinolines inhibited heme polymerization. We could find no direct correlation b...

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Bibliografische Detailangaben

Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Hawley, Shaun R., Bray, Patrick G., Mungthin, Mathirut, Atkinson, Jill D., O’Neill, Paul M., Ward, Stephen A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105517/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.682
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