Relationship between Antimalarial Drug Activity, Accumulation, and Inhibition of Heme Polymerization in Plasmodium falciparum In Vitro

We have investigated the contribution of drug accumulation and inhibition of heme polymerization to the in vitro activities of a series of antimalarial drugs. Only those compounds exhibiting structural relatedness to the quinolines inhibited heme polymerization. We could find no direct correlation b...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Hawley, Shaun R., Bray, Patrick G., Mungthin, Mathirut, Atkinson, Jill D., O’Neill, Paul M., Ward, Stephen A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105517/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517951/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.682
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