Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

Bis(isopropyloxymethylcarbonyl) 9-R-(2-phosphonomethoxypropyl)adenine [bis(POC)PMPA] has been identified as a novel prodrug of PMPA. The anti-human immunodeficiency virus activity of bis(POC)PMPA was >100-fold greater than that of PMPA in both an established T-cell line and primary peripheral blood...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Robbins, Brian L., Srinivas, Ranga V., Kim, Choung, Bischofberger, Norbert, Fridland, Arnold
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517941/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.612
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