Mutations in Topoisomerase IV and DNA Gyrase of Staphylococcus aureus: Novel Pleiotropic Effects on Quinolone and Coumarin Activity

Previous studies have shown that topoisomerase IV and DNA gyrase interact with quinolones and coumarins in different ways. The MICs of coumarins (novobiocin and coumermycin) for MT5, a Staphylococcus aureus nov mutant, are higher than those for wild-type strains. Sequencing the gyrB gene encoding on...

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Bibliografische gegevens

Gepubliceerd in:	Antimicrob Agents Chemother
Hoofdauteurs:	Fournier, Bénédicte, Hooper, David C.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 1998
Onderwerpen:	Mechanisms of Resistance
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105466/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9449271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.1.121
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