Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.

A 4.2-kb DNA fragment conferring quinolone resistance was cloned from a quinolone-resistant clinical isolate of Staphylococcus aureus and was shown to possess a part of the grlB gene and a mutated grlA gene. S-80-->F and E-84-->K mutations in the grlA gene product were responsible for the quinolone...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Yamagishi, J, Kojima, T, Oyamada, Y, Fujimoto, K, Hattori, H, Nakamura, S, Inoue, M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163283/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8723458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.5.1157
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