Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental Enterococcus faecalis Endocarditis

The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 μg/...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Join-Lambert, Olivier, Mainardi, Jean-Luc, Cuvelier, Catherine, Dautrey, Sophie, Farinotti, Robert, Fantin, Bruno, Carbon, Claude
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9527811/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.2.468
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