Genetic essential tremor in γ-aminobutyric acid(A) receptor α1 subunit knockout mice

Essential tremor is the most common movement disorder and has an unknown etiology. Here we report that γ-aminobutyric acid(A) (GABA(A)) receptor α1(–/–) mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease. We tested mice with essential...

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Auteurs principaux: Kralic, Jason E., Criswell, Hugh E., Osterman, Jessica L., O’Buckley, Todd K., Wilkie, Mary E., Matthews, Douglas B., Hamre, Kristin, Breese, George R., Homanics, Gregg E., Morrow, A. Leslie
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1052003/
https://ncbi.nlm.nih.gov/pubmed/15765150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523625
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