A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection

Cytotoxic T cells secrete perforin to kill virus-infected cells. In this study we show that perforin also plays a role in immune regulation. Perforin-deficient (perf −/−) mice chronically infected with lymphocytic choriomeningitis virus (LCMV) contained greater numbers of antiviral T cells compared...

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Detalhes bibliográficos
Main Authors: Matloubian, Mehrdad, Suresh, M., Glass, Alison, Galvan, Marisa, Chow, Kit, Whitmire, Jason K., Walsh, Craig M., Clark, William R., Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC104500/
https://ncbi.nlm.nih.gov/pubmed/9971838
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