V3 Recombinants Indicate a Central Role for CCR5 as a Coreceptor in Tissue Infection by Human Immunodeficiency Virus Type 1

Binding of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 to both CD4 and one of several chemokine receptors (coreceptors) permits entry of virus into target cells. Infection of tissues may establish latent viral reservoirs as well as cause direct pathologic effects that...

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Main Authors: Chan, Stephen Y., Speck, Roberto F., Power, Christopher, Gaffen, Sarah L., Chesebro, Bruce, Goldsmith, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Virus-Cell Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC104480/
https://ncbi.nlm.nih.gov/pubmed/9971818
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