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Extensive Mutagenesis of the Hepatitis B Virus Core Gene and Mapping of Mutations That Allow Capsid Formation

We generated a large number of mutations in the hepatitis B virus (HBV) core gene inserted into a bacterial expression vector. The new mutagenesis procedure generated deletions and insertions (as sequence repeats) of various lengths at random positions between M1 and E145 but not substitutions. The...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Koschel, Matthias, Thomssen, Reiner, Bruss, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC104460/
https://ncbi.nlm.nih.gov/pubmed/9971798
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