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Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

Recent studies indicate that phosphatidylinositide-3OH kinase (PI3K)-induced S6 kinase (S6K1) activation is mediated by protein kinase B (PKB). Support for this hypothesis has largely relied on results obtained with highly active, constitutively membrane-localized alleles of wild-type PKB, whose act...

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Auteurs principaux: Dufner, Almut, Andjelkovic, Mirjana, Burgering, Boudewijn M. T., Hemmings, Brian A., Thomas, George
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1999
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC104410/
https://ncbi.nlm.nih.gov/pubmed/10330191
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