Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins, develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α). Macrophages derived from these mice oversecrete TNF-α, by a mechanism that involves stabilization of TNF-α mRNA, a...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Lai, Wi S., Carballo, Ester, Strum, Julie R., Kennington, Elizabeth A., Phillips, Ruth S., Blackshear, Perry J.
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 1999
Matèries:	Gene Expression
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104391/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10330172/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.6.4311
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