Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH zinc finger proteins, develop an inflammatory syndrome mediated by excess tumor necrosis factor alpha (TNF-α). Macrophages derived from these mice oversecrete TNF-α, by a mechanism that involves stabilization of TNF-α mRNA, a...

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Main Authors: Lai, Wi S., Carballo, Ester, Strum, Julie R., Kennington, Elizabeth A., Phillips, Ruth S., Blackshear, Perry J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC104391/
https://ncbi.nlm.nih.gov/pubmed/10330172
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