Increased Instability of Human CTG Repeat Tracts on Yeast Artificial Chromosomes during Gametogenesis

Expansion of trinucleotide repeat tracts has been shown to be associated with numerous human diseases. The mechanism and timing of the expansion events are poorly understood, however. We show that CTG repeats, associated with the human DMPK gene and implanted in two homologous yeast artificial chrom...

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Autors principals: Cohen, Haim, Sears, Dorothy D., Zenvirth, Drora, Hieter, Philip, Simchen, Giora
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC104374/
https://ncbi.nlm.nih.gov/pubmed/10330155
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