Increased Instability of Human CTG Repeat Tracts on Yeast Artificial Chromosomes during Gametogenesis

Expansion of trinucleotide repeat tracts has been shown to be associated with numerous human diseases. The mechanism and timing of the expansion events are poorly understood, however. We show that CTG repeats, associated with the human DMPK gene and implanted in two homologous yeast artificial chrom...

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Bibliografske podrobnosti

izdano v:	Mol Cell Biol
Principais autores:	Cohen, Haim, Sears, Dorothy D., Zenvirth, Drora, Hieter, Philip, Simchen, Giora
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis 1999
Teme:	DNA Dynamics and Chromosome Structure
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10330155/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.6.4153
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