Induction of Antiviral Antibodies by DNA Immunization Requires neither Perforin-Mediated nor CD8(+)-T-Cell-Mediated Lysis of Antigen-Expressing Cells

DNA immunization induces antibodies to the encoded protein, which indicates that the protein must gain access to the extracellular milieu, allowing it to interact with naïve B lymphocytes. It has been suggested that antigen release may be effected by cytotoxic-T-lymphocyte-mediated lysis of transfec...

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Pubblicato in:	J Virol
Autori principali:	Hassett, Daniel E., Zhang, Jie, Whitton, J. Lindsay
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Vaccines and Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10438882/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.9.7870-7873.1999
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