Drastic Fitness Loss in Human Immunodeficiency Virus Type 1 upon Serial Bottleneck Events

Muller’s ratchet predicts fitness losses in small populations of asexual organisms because of the irreversible accumulation of deleterious mutations and genetic drift. This effect should be enhanced if population bottlenecks intervene and fixation of mutations is not compensated by recombination. To...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Yuste, Eloisa, Sánchez-Palomino, Sonsoles, Casado, Concha, Domingo, Esteban, López-Galíndez, Cecilio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Recombination and Evolution
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104031/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10074121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.4.2745-2751.1999
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