Drastic Fitness Loss in Human Immunodeficiency Virus Type 1 upon Serial Bottleneck Events

Muller’s ratchet predicts fitness losses in small populations of asexual organisms because of the irreversible accumulation of deleterious mutations and genetic drift. This effect should be enhanced if population bottlenecks intervene and fixation of mutations is not compensated by recombination. To...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Yuste, Eloisa, Sánchez-Palomino, Sonsoles, Casado, Concha, Domingo, Esteban, López-Galíndez, Cecilio
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1999
Fag:	Recombination and Evolution
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104031/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10074121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.4.2745-2751.1999
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