Changes in Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Responsible for the Pathogenicity of a Multiply Passaged Simian-Human Immunodeficiency Virus (SHIV-HXBc2)

In vivo passage of a poorly replicating, nonpathogenic simian-human immunodeficiency virus (SHIV-HXBc2) generated an efficiently replicating virus, KU-1, that caused rapid CD4(+) T-lymphocyte depletion and AIDS-like illness in monkeys (S. V. Joag, Z. Li, L. Foresman, E. B. Stephens, L.-J. Zhao, I. A...

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Autori principali: Cayabyab, Mark, Karlsson, Gunilla B., Etemad-Moghadam, Bijan A., Hofmann, Wolfgang, Steenbeke, Tavis, Halloran, Matilda, Fanton, John W., Axthelm, Michael K., Letvin, Norman L., Sodroski, Joseph G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC103917/
https://ncbi.nlm.nih.gov/pubmed/9882298
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