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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation of HSV-1 from latency. We previously reported that insertion of the LAT promoter and just the first 1.5 kb of the 8.3-kb LAT gene into an ectopic location in the virus...

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Udgivet i:J Virol
Principais autores: Perng, Guey-Chuen, Slanina, Susan M., Yukht, Ada, Drolet, Barbara S., Keleher, William, Ghiasi, Homayon, Nesburn, Anthony B., Wechsler, Steven L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103911/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9882292/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.2.920-929.1999
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