Identical 371-Base-Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes

The herpes simplex virus type 1 (HSV-1) LAT gene is the only viral gene abundantly transcribed during latency. LAT null mutants created with strains McKrae and 17syn+ are impaired for both in vivo spontaneous and in vivo-induced reactivation. Thus, LAT is essential for efficient in vivo-induced and...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Loutsch, Jeannette M., Perng, Guey-Chuen, Hill, James M., Zheng, Xiaodong, Marquart, Mary E., Block, Timothy M., Ghiasi, Homayon, Nesburn, Anthony B., Wechsler, Steven L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103886/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9847385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.1.767-771.1999
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