Identical 371-Base-Pair Deletion Mutations in the LAT Genes of Herpes Simplex Virus Type 1 McKrae and 17syn+ Result in Different In Vivo Reactivation Phenotypes

The herpes simplex virus type 1 (HSV-1) LAT gene is the only viral gene abundantly transcribed during latency. LAT null mutants created with strains McKrae and 17syn+ are impaired for both in vivo spontaneous and in vivo-induced reactivation. Thus, LAT is essential for efficient in vivo-induced and...

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Main Authors: Loutsch, Jeannette M., Perng, Guey-Chuen, Hill, James M., Zheng, Xiaodong, Marquart, Mary E., Block, Timothy M., Ghiasi, Homayon, Nesburn, Anthony B., Wechsler, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC103886/
https://ncbi.nlm.nih.gov/pubmed/9847385
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