Herpes Simplex Virus Processivity Factor UL42 Imparts Increased DNA-Binding Specificity to the Viral DNA Polymerase and Decreased Dissociation from Primer-Template without Reducing the Elongation Rate

Herpes simplex virus DNA polymerase consists of a catalytic subunit, Pol, and a processivity subunit, UL42, that, unlike other established processivity factors, binds DNA directly. We used gel retardation and filter-binding assays to investigate how UL42 affects the polymerase-DNA interaction. The P...

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Pubblicato in:	J Virol
Autori principali:	Weisshart, Klaus, Chow, Connie S., Coen, Donald M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103808/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9847307/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.1.55-66.1999
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