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Overexpression of a Dominant-Negative Allele of SEC4 Inhibits Growth and Protein Secretion in Candida albicans

Candida albicans SEC4 was cloned by complementing the Saccharomyces cerevisiae sec4-8 mutation, and its deduced protein product (Sec4p) was 63% identical to S. cerevisiae Sec4p. One chromosomal SEC4 allele in C. albicans CAI4 was readily disrupted by homologous gene targeting, but efforts to disrupt...

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Udgivet i:J Bacteriol
Principais autores: Mao, Yuxin, Kalb, Vernon F., Wong, Brian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Eukaryotic Cells
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103685/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10572126/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.181.23.7235-7242.1999
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