Doxorubicin Overproduction in Streptomyces peucetius: Cloning and Characterization of the dnrU Ketoreductase and dnrV Genes and the doxA Cytochrome P-450 Hydroxylase Gene

Doxorubicin-overproducing strains of Streptomyces peucetius ATCC 29050 can be obtained through manipulation of the genes in the region of the doxorubicin (DXR) gene cluster that contains dpsH, the dpsG polyketide synthase gene, the putative dnrU ketoreductase gene, dnrV, and the doxA cytochrome P-45...

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Detalhes bibliográficos
Main Authors: Lomovskaya, Natalie, Otten, Sharee L., Doi-Katayama, Yukiko, Fonstein, Leonid, Liu, Xiao-Chun, Takatsu, Toshio, Inventi-Solari, Augusto, Filippini, Silvia, Torti, Francesca, Colombo, Anna Luisa, Hutchinson, C. Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC103563/
https://ncbi.nlm.nih.gov/pubmed/9864344
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