Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages

A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described. The phosphorodithioate linkage is introduced using a new dithiophosphorylating reagent DPSE-SP(S)Cl(2) where DPSE = 2-diphenylmethylsilylethyl. This group is removed quickly using tetra-butylammonium fluor...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Capaldi, Daniel C., Cole, Douglas L., Ravikumar, Vasulinga T.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	NAR Methods Online
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103313/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.9.e40
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