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Highly efficient solid phase synthesis of oligonucleotide analogs containing phosphorodithioate linkages
A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described. The phosphorodithioate linkage is introduced using a new dithiophosphorylating reagent DPSE-SP(S)Cl(2) where DPSE = 2-diphenylmethylsilylethyl. This group is removed quickly using tetra-butylammonium fluor...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC103313/ https://ncbi.nlm.nih.gov/pubmed/10756207 |
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