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Characterization of Candida albicans RNA triphosphatase and mutational analysis of its active site

The RNA triphosphatase component (CaCet1p) of the mRNA capping apparatus of the pathogenic fungus Candida albicans differs mechanistically and structurally from the RNA triphosphatase of mammals. Hence, CaCet1p is an attractive antifungal target. Here we identify a C-terminal catalytic domain of CaC...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pei, Yi, Lehman, Kevin, Tian, Ligeng, Shuman, Stewart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC103306/
https://ncbi.nlm.nih.gov/pubmed/10756187
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