A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme
We synthesized three types of 11mer substrate, namely the natural substrate S11O and the thiosubstituted substrates S11SpS and S11RpS, in which the respective pro-Sp and pro-Rp oxygen atoms were replaced by sulfur, and subjected them to detailed kinetic analysis in the cleavage reaction catalyzed by...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10734192/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.8.1730 |
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