4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1

Shiga toxin 1 (Stx1) catalyses the removal of a unique and specific adenine from 28S RNA in ribosomes (RNA-N-glycosidase activity) and the release of multiple adenines from DNA (DNA glycosylase activity). Added adenine behaves as an uncompetitive inhibitor of the RNA-N-glycosidase reaction binding m...

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Hauptverfasser: Brigotti, Maurizio, Carnicelli, Domenica, Accorsi, Paola, Rizzi, Simona, Montanaro, Lucio, Sperti, Simonetta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC102733/
https://ncbi.nlm.nih.gov/pubmed/10871371
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