Resolution of a Holliday junction by vaccinia topoisomerase requires a spacer DNA segment 3′ of the CCCTT↓ cleavage sites

Vaccinia virus DNA topoisomerase catalyzes reso­lution of synthetic Holliday junctions in vitro. The mechanism entails concerted transesterifications at two recognition sites, 5′-CCCTT↓, that are opposed within a partially mobile four-way junction. Efficient resolution occurs on a junction with a 10...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Sekiguchi, JoAnn, Cheng, Chonghui, Shuman, Stewart
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102645/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908320/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.14.2658
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