Optimized synthesis of phosphorothioate oligodeoxyribonucleotides substituted with a 5′-protected thiol function and a 3′-amino group

A new deprotection procedure enables a medium scale preparation of phosphodiester and phosphorothioate oligonucleotides substituted with a protected thiol function at their 5′-ends and an amino group at their 3′-ends in good yield (up to 72 OD units/µmol for a 19mer phosphorothioate). Syntheses of 3...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Aubert, Yves, Bourgerie, Sylvain, Meunier, Laurent, Mayer, Roger, Roche, Annie-Claude, Monsigny, Michel, Thuong, Nguyen T., Asseline, Ulysse
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2000
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10637335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.3.818
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