Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

The mutagenic and carcinogenic effects of simple alkylating agents are mainly due to O(6)-alkylation of guanine in DNA. This lesion results in transition mutations. In both prokaryotic and eukaryotic cells, repair is effected by direct reversal of the damage by a suicide protein, O(6)-alkylguanine-D...

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Publicado en:	Nucleic Acids Res
Autores principales:	Wibley, Jane E. A., Pegg, Anthony E., Moody, Peter C. E.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 2000
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10606635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.2.393
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