Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase
The mutagenic and carcinogenic effects of simple alkylating agents are mainly due to O(6)-alkylation of guanine in DNA. This lesion results in transition mutations. In both prokaryotic and eukaryotic cells, repair is effected by direct reversal of the damage by a suicide protein, O(6)-alkylguanine-D...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10606635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.2.393 |
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