Inhibition of in vitro and ex vivo translation by a transplatin-modified oligo(2′-O-methylribonucleotide) directed against the HIV-1 gag-pol frameshift signal

A 2′-O-methylribooligonucleotide containing a G1·U·G3 triad modified by trans-diamminedichloro-platinum(II) was targeted to the RNA region responsible for the gag–pol frameshifting during translation of the HIV-1 mRNA. The binding of the platinated oligonucleotide to its target RNA induced a rearran...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Aupeix-Scheidler, Karine, Chabas, Sandrine, Bidou, Laure, Rousset, Jean-Pierre, Leng, Marc, Toulmé, Jean-Jacques
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102513/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10606641/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.2.438
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