Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

To investigate the effect of mutations in the p53 C-terminal domain on MDM2-mediated degradation, we introduced single and multiple point mutations into a human p53 cDNA at four putative acetylation sites (amino acid residues 372, 373, 381, and 382). Substitution of all four lysine residues by alani...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Nakamura, Seiichi, Roth, Jack A., Mukhopadhyay, Tapas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102195/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11094089/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.24.9391-9398.2000
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