Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the TNF Promoter Region

Stimulation of the NF-κB pathway often causes p65-p50 and p50-p50 dimers to be simultaneously present in the cell nucleus. A natural polymorphism at nucleotide −863 in the human TNF promoter (encoding tumor necrosis factor [TNF]) region provides an opportunity to dissect the functional interaction o...

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Autores principales: Udalova, Irina A., Richardson, Anna, Denys, Agnes, Smith, Clive, Ackerman, Hans, Foxwell, Brian, Kwiatkowski, Dominic
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Transcriptional Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC102169/
https://ncbi.nlm.nih.gov/pubmed/11094063
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