Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation

The mammalian NF-κB p52:p52 homodimer together with its cofactor Bcl3 activates transcription of κB sites with a central G/C base pair (bp), while it is inactive toward κB sites with a central A/T bp. To understand the molecular basis for this unique property of p52, we have determined the crystal s...

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Autores principales:	Wenfei Pan, Vladimir A Meshcheryakov, Tianjie Li, Yi Wang, Gourisankar Ghosh, Vivien Ya-Fan Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2023-02-01
Colección:	eLife
Materias:	DNA conformation NF-κB crystal structure MD simulation transcriptional regulation thermodynamics
Acceso en línea:	https://elifesciences.org/articles/86258
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